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Unlike many bands flaunting their level of strangeness, they did get an unusual amount of attention (albeit brief), becoming fleeting MTV darlings, which is where my young ears and eyes first crossed their path. Lastly, I’ll mention that some folks say Stump sound like Primus, but my only retort is that they have it exactly backwards, for Primus do indeed sound at times like Stump. Perhaps this hypothetical is just as inappropriate as dragging Beefheart into the discussion, but at least it’s a little more in line with what Stump actually achieves on record. The desperate stab at signifying that I’ve been partial to over the years to describe A Fierce Pancake is Residential, for it certainly holds touches that remind me of something Ralph Records might’ve concocted for potential pop-chart consumption during the same decade. They do both feature an unrestrained angularity at times, but it’s used to different ends. And Don’s blues-based zonked hippie aesthetic is fundamentally different from Stump’s subversion of pop song structure. I mean, it’s weird, but it’s not that weird. Those unfamiliar with this nomenclature should understand that it concerns the pseudonym of the late great Don Van Vliet, and that it’s usually shorthand for “this is so freaking weird and unlike anything else I’ve heard that I’m forced to make a broad and ill-suited comparison.”įor A Fierce Pancake sounds very little like Captain Beefheart. No, Stump was so unlike their contemporaries that the most frequent comparison they received was through the dubious adjective Beefheartian. And the band was included on the now legendary C86 sampler released by the New Musical Express, but they frankly stick out like a throbbing digit amongst that release’s rough template of indie jangle and noise pop. Stump did hail from Great Britain that much was obvious. Just where did this record come from? Yes, it seemed they’d chosen their name quite well. And it was exceptionally smart, but the band felt more like cagey, occasionally inscrutable pranksters than savvy and sober intellectuals. It was surely bizarre, but was also highly structured. The music’s bent was deeply non-conformist yet not substantially indebted to punk precedent. When A Fierce Pancake first appeared stateside, it served as many listeners’ introduction to a band that to put it mildly presented a real head-scratcher. One example is Stump, whose 1988 LP A Fierce Pancake combined an extremely oddball sensibility with well-conceived, surprisingly enduring music. This foundational population-based genetic study of a common speech disorder reports the findings of a clinically ascertained study of developmental stuttering and highlights the need for further research.There are great bands and there are truly peculiar bands, and sometimes the twain does meet. In addition, we identified 15 loci reaching suggestive significance (p < 5 × 10 −6). Meta-analysis of these genome-wide association studies identified a genome-wide significant (GWS) signal for clinically reported developmental stuttering in the general population: a protective variant in the intronic or genic upstream region of SSUH2 (rs113284510, protective allele frequency = 7.49%, Z = −5.576, p = 2.46 × 10 −8) that acts as an expression quantitative trait locus (eQTL) in esophagus-muscularis tissue by reducing its gene expression. We conducted a trans-ancestry genome-wide association study (GWAS) and meta-analysis of developmental stuttering in two primary datasets: The International Stuttering Project comprising 1,345 clinically ascertained cases from multiple global sites and 6,759 matched population controls from the biobank at Vanderbilt University Medical Center (VUMC), and 785 self-reported stuttering cases and 7,572 controls ascertained from The National Longitudinal Study of Adolescent to Adult Health (Add Health). Family, twin, and segregation studies overwhelmingly support a strong genetic influence on stuttering risk however, its complex mode of inheritance combined with thus-far underpowered genetic studies contribute to the challenge of identifying and reproducing genes implicated in developmental stuttering susceptibility. Despite a lifetime prevalence of at least 5%, developmental stuttering, characterized by prolongations, blocks, and repetitions of speech sounds, remains a largely idiopathic speech disorder.